Amyloid Beta Oligomer Formation Analysis by Photon Counting Histogram
نویسندگان
چکیده
منابع مشابه
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
Multiple isoforms of aggregation-prone proteins are present under physiological conditions and have the propensity to assemble into co-oligomers with different properties from self-oligomers, but this process has not been quantitatively studied to date. We have investigated the amyloid-β (Aβ) peptide, associated with Alzheimer's disease, and the aggregation of its two major isoforms, Aβ40 and A...
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Background: The functional signaling unit of G protein coupled receptors is debated to be a monomer, dimer or higher order oligomer. Results: Fluorescence correlation spectroscopy and photon counting histogram analysis, with single molecule sensitivity, identified 5-HT 2C receptor dimers without monomers or tetramers. Conclusion: Dimers are the basic signaling unit. Significance: Bivalent ligan...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.376